Thrombosis and HaemophiliA
The Western Australian Centre for Thrombosis and Haemostasis (WACTH) research group, led by Professor Ross Baker, has major research interests in the study of thrombosis and bleeding disorders. Our ongoing projects are focused on identifying and characterising autoantibodies and non-coding RNA species that act to deregulate coagulation factors leading to thrombophilic disorders. The major projects include: 1. Develop immunoassays to characterise the neutralising autoantibodies targeting the anti-coagulant protein, ADAMTS13, in thrombotic thrombocytopenic purpura, 2. Investigate the role of folate receptor alpha autoantibodies and folate deficiency in thrombosis and recurrent miscarriages and 3. Investigate microRNAs that are regulated by high levels of oestrogen during pregnancy and oral contraceptive use which downregulate coagulation factors leading to deficiencies in key haemostatic proteins and an elevated risk of venous thrombosis. Based in Murdoch University and within an emerging health precinct, WACTH amalgamates clinical and basic science research activities in precipitating translational outcomes for the treatment and diagnosis of thrombosis and bleeding disorders.